Sabelli H C, Vazquez A J, Flavin D
Psychopharmacologia. 1975 May 28;42(2):117-25. doi: 10.1007/BF00429541.
The electrophysiological and behavioral effects of phenylethanolamine (OHPEA) and of its precursor 2-phenylethylamine (PEA) were studied in mice and rabbits. In animals pretreated with MAOI, PEA was found to exert strong amphetamine-like effects, EEG alerting, reduction of visual evoked responses, increased locomotor activity, and blockade of tonic seizures induced by electroshock. OHPEA exerted weaker amphetamine-like effects. Inhibition of dopamine-beta-hydroxylase increased most of the effects of PEA. In non-pretreated animals, OHPEA was found to shorten electroshock latency and to prolong the duration of visual evoked responses. PEA (but not OHPEA) potentiated the excitement induced by delta9-tetrahydrocannabinol in MAOI-pretreated mice. Reserpine pretreatment reduced but did not abolish the CNS effects of OHPEA and PEA. One may speculate that endogenous PEA is more likely to serve as a modulator for ergotropic functions than is endogenous OHPEA.
在小鼠和兔子身上研究了苯乙醇胺（OHPEA）及其前体2-苯乙胺（PEA）的电生理和行为效应。在用单胺氧化酶抑制剂（MAOI）预处理的动物中，发现PEA具有强烈的类似苯丙胺的效应，如脑电图警觉、视觉诱发电位降低、运动活动增加以及对电休克诱导的强直性惊厥的阻断作用。OHPEA的类似苯丙胺的效应较弱。抑制多巴胺-β-羟化酶增强了PEA的大部分效应。在未预处理的动物中，发现OHPEA可缩短电休克潜伏期并延长视觉诱发电位的持续时间。在MAOI预处理的小鼠中，PEA（但不是OHPEA）增强了δ9-四氢大麻酚诱导的兴奋作用。利血平预处理减轻但并未消除OHPEA和PEA对中枢神经系统的作用。人们可以推测，内源性PEA比内源性OHPEA更有可能作为促肾上腺能功能的调节剂。
