Ameen A R
Experientia. 1996 Mar 15;52(3):189-211. doi: 10.1007/BF01920707.
The problem on integration and control of the various processes of the metazoan organism is a major challenge to the physiologist. The traditional research strategy in dealing with the problem is neuron-oriented and its roots extend back into the last century when knowledge of hormones was lacking. In the present article, the traditional strategy is analyzed in the light of available data and its logical basis is questioned. Different levels of communication are supposed to occur in the animal or human body. Circulating hormones are responsible for the highest level of communication that occurs between organs or tissues. The central concept in the article is that regulation of circulating hormones constitutes a higher level of control relative to regulation of intercellular hormones. This is regardless of whether the latter occurs in the nervous system or elsewhere. The approach is utilized in defining the mechanism that integrates and controls the part processes of the body. The mechanism is defined as endothelial; the vascular endothelial system is the controlling part and the nervous system is one of the subordinate parts. Thanks to the new approach, meaningful biological explanations of major psychiatric disorders are now possible.
后生动物机体各种过程的整合与控制问题，是生理学家面临的一项重大挑战。处理该问题的传统研究策略是以神经元为导向的，其根源可追溯到上世纪，当时对激素的了解还很匮乏。在本文中，我们根据现有数据对传统策略进行了分析，并对其逻辑基础提出了质疑。动物或人体中存在不同层次的通讯。循环激素负责器官或组织之间最高层次的通讯。本文的核心观点是，相对于细胞间激素的调节而言，循环激素的调节构成了更高层次的控制。无论后者发生在神经系统还是其他地方，都是如此。这种方法被用于定义整合和控制身体各部分过程的机制。该机制被定义为内皮机制；血管内皮系统是控制部分，而神经系统是从属部分之一。得益于这种新方法，现在有可能对主要精神疾病作出有意义的生物学解释。
