Burleson R L, Holman B L, Tow D E
Surg Gynecol Obstet. 1975 Sep;141(3):379-82.
Autologous peripheral blood leukocytes, labeled in vitro with 67Ga citrate, have been studied in 20 patients as a radioactive carrier for the scintigraphic visualization of septic inflammatory areas. 67Ga citrate was added to venous whole blood; following incubation, the blood was centrifugated, and the packed cells were reinfused. Scintiscans were obtained four and 24 hours later. The inflammatory process was demonstrated in nine of nine patients with confirmed sepsis. Eleven patients without sepsis had normal scans. There were no false-negative scans and one-false-positive scan. The selective accumulation of the gallium labeled leukocytes in areas of septic inflammation was sufficient to allow scintigraphic demonstration of the inflammatory area.
用枸橼酸镓在体外标记的自体外周血白细胞，已在20例患者中作为放射性载体用于脓毒性炎症区域的闪烁显像研究。将枸橼酸镓加入静脉全血中；孵育后，血液离心，然后回输浓缩细胞。4小时和24小时后进行闪烁扫描。在9例确诊为脓毒症的患者中，有9例显示出炎症过程。11例无脓毒症的患者扫描结果正常。没有假阴性扫描结果，只有1例假阳性扫描结果。镓标记的白细胞在脓毒性炎症区域的选择性聚集足以通过闪烁显像显示炎症区域。
