Andersen B R, English D, Akalin H E, Henderson W
Arch Intern Med. 1975 Aug;135(8):1067-71.
Canine leukocytes were labeled with a gamma-ray emitting isotope by permitting them to phagocytize technetium Tc 99m sulfur colloid particles in vitro and removing the unphagocytized particles by washing the cells. The labeled cells were reinfused intravenously into the donor dogs. Scintigraphic scans were performed 4 and 24 hours following the leukocyte infusion. In animals with sterile and infected intramuscular abscesses and pulmonary infections, it was possible to localize the lesions by scintigraphic scanning four hours following administration of labeled leukocytes. In one experiment, a positive scan was observed 24 hours after the leukocyte infusion. It was also shown that labeled leukocytes tend to concentrate in abscess fluid. These results suggest that technetium Tc 99m sulfur colloid-labeled leukocytes may be a useful diagnostic tool in localizing abscesses and inflammatory lesions in humans.
通过让犬类白细胞在体外吞噬锝Tc 99m硫胶体颗粒并用洗涤细胞的方法去除未被吞噬的颗粒，从而用发射伽马射线的同位素对犬类白细胞进行标记。将标记后的细胞静脉回输给供体犬。在白细胞输注后4小时和24小时进行闪烁扫描。在患有无菌性和感染性肌肉脓肿及肺部感染的动物中，在注射标记白细胞4小时后通过闪烁扫描能够定位病变部位。在一项实验中，白细胞输注24小时后观察到阳性扫描结果。还表明标记的白细胞倾向于在脓肿液中聚集。这些结果表明，锝Tc 99m硫胶体标记的白细胞可能是定位人类脓肿和炎症性病变的一种有用的诊断工具。
