Bonnemain B
Rev Hist Pharm (Paris). 2000;48(325):101-16.
Iodine and iodide used to be very successful drugs, sometimes at massive doses. Highly iodinated oil such as lipiodol from Lafay discovered in 1901 were part of expanding the therapeutic use of iodine for various pathologies such as syphilis, cardiovascular and respiratory diseases, leprosy, goiter... The present publication reviews unpublished documents and publications from 1901 to 1930 on lipiodol to give an overview of therapeutic indications for this agent and the rationale behind it. In some areas such as asthma, iodide was still in use until the eighties. Prevention and treatment of endemic goiter is the only remaining domain for the therapeutic usage of lipiodol. It is the only reason why this product is on the WHO essential drugs list.
碘和碘化物曾是非常成功的药物，有时使用的剂量很大。1901年发现的高度碘化油，如来自拉法伊的碘油，是扩大碘在梅毒、心血管和呼吸系统疾病、麻风病、甲状腺肿等各种病症治疗用途的一部分。本出版物回顾了1901年至1930年关于碘油的未发表文献和出版物，以概述该药物的治疗适应症及其背后的原理。在哮喘等一些领域，直到80年代碘化物仍在使用。预防和治疗地方性甲状腺肿是碘油唯一仍在使用的治疗领域。这是该产品被列入世界卫生组织基本药物清单的唯一原因。
