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Some effects of piracetam (UCB 6215, Nootropyl) on chronic schizophrenia.

作者信息

Dimond S J, Scammell R E, Pryce I G, Huws D, Gray C

出版信息

Psychopharmacology (Berl). 1979 Sep;64(3):341-8. doi: 10.1007/BF00427522.

DOI:10.1007/BF00427522
PMID:116278
Abstract

A study is described of effects of a nootropic drug on chronic schizophrenia. The nootropic drugs act on the central nervous system with the cerebral cortex as their target. Chronic schizophrenic patients on the drug showed improvement in object naming and in tests where the patient was required to indicate the number of times he had been tapped. Improvements were also noted in learning and memory tasks. In dichotic listening the patients showed a reduction in the amount of incorrect verbal responses produced. There were no improvements in symptom rating or social behaviour rating. These results suggest some cognitive improvement but little if any change in the disease state of the patient.

摘要

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Some effects of piracetam (UCB 6215, Nootropyl) on chronic schizophrenia.
Psychopharmacology (Berl). 1979 Sep;64(3):341-8. doi: 10.1007/BF00427522.
2
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本文引用的文献

1
A simple and reliable subclassification of chronic schizophrenia.慢性精神分裂症的一种简单可靠的亚分类。
J Ment Sci. 1961 Sep;107:862-75. doi: 10.1192/bjp.107.450.862.
2
Visual-motor disorders in infants at risk for schizophrenia.精神分裂症高危婴儿的视觉运动障碍
Arch Gen Psychiatry. 1972 Nov;27(5):594-8. doi: 10.1001/archpsyc.1972.01750290020003.
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Quantitative brain measurements in chronic schizophrenia.
Br J Psychiatry. 1972 Sep;121(562):259-64. doi: 10.1192/bjp.121.3.259.
AMPA受体正向调节剂5-(1-哌啶基羰基)-2,1,3-苯并恶二唑(CX691)对大鼠认知促进作用的评估。
Psychopharmacology (Berl). 2009 Jan;202(1-3):343-54. doi: 10.1007/s00213-008-1325-2. Epub 2008 Sep 16.
4
Multiple molecular determinants for allosteric modulation of alternatively spliced AMPA receptors.可变剪接的AMPA受体变构调节的多种分子决定因素。
J Neurosci. 2003 Nov 26;23(34):10953-62. doi: 10.1523/JNEUROSCI.23-34-10953.2003.
5
LY404187: a novel positive allosteric modulator of AMPA receptors.LY404187:一种新型的α-氨基-3-羟基-5-甲基-4-异恶唑丙酸(AMPA)受体正向变构调节剂。
CNS Drug Rev. 2002 Fall;8(3):255-82. doi: 10.1111/j.1527-3458.2002.tb00228.x.
6
Piracetam in elderly psychiatric patients with mild diffuse cerebral impairment.吡拉西坦用于患有轻度弥漫性脑损伤的老年精神病患者。
Psychopharmacology (Berl). 1983;81(2):100-6. doi: 10.1007/BF00429000.
4
Mechanisms of interhemispheric transfer of visual information in rats.大鼠视觉信息半球间传递的机制
Acta Neurobiol Exp (Wars). 1973;33(4):673-88.
5
Brain disconnection and schizophrenia.大脑连接中断与精神分裂症
Br J Psychiatry. 1973 Dec;123(577):661-2. doi: 10.1192/bjp.123.6.661.
6
The "nootropic" approach to the pharmacology of the integrative activity of the brain.关于大脑整合活动药理学的“促智”方法。
Cond Reflex. 1973 Apr-Jun;8(2):108-15. doi: 10.1007/BF03000311.
7
Ictal and interictal psychiatric manifestations in epilepsy: specific or non-specific? A critical review of some of the evidence.癫痫发作期和发作间期的精神症状:是特异性的还是非特异性的?对一些证据的批判性综述。
Epilepsia. 1972 Dec;13(6):773-83. doi: 10.1111/j.1528-1157.1972.tb05162.x.
8
Bimodality and lateral asymmetry of skin conductance orienting activity in schizophrenics: replication and evidence of lateral asymmetry in patients with depression and disorders of personality.精神分裂症患者皮肤电导率定向活动的双峰性和侧向不对称性:抑郁症患者和人格障碍患者侧向不对称性的复制及证据
Biol Psychiatry. 1974 Feb;8(1):55-73.
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Hand preference patterns in psychiatric patients.精神病患者的用手偏好模式。
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Increase in the power of human memory in normal man through the use of drugs.通过使用药物提高正常人的记忆力。
Psychopharmacology (Berl). 1976 Sep 29;49(3):307-9. doi: 10.1007/BF00426834.