Trigg M E, Geier M R, LaPolla R J, Kamerow H N, Merril C R
Am J Clin Nutr. 1975 Sep;28(9):947-9. doi: 10.1093/ajcn/28.9.947.
Leucine-starved mice placed on a diet supplemented with the immediate precursor of leucine, alpha-ketoisocaproic acid, regain lost weight. This weight gain is similar to that observed when the leucine-starved mice are provided with leucine in their diet. Mice on a leucine-free diet supplemented with alpha-ketoisovaleric acid, the first compound in the leucine biosynthetic pathway, continued to lose weight as quickly as mice on leucine-deficient diets.
给处于亮氨酸饥饿状态的小鼠喂食添加了亮氨酸的直接前体α-酮异己酸的饮食后，它们恢复了体重。这种体重增加与给亮氨酸饥饿的小鼠喂食亮氨酸时观察到的情况相似。在无亮氨酸饮食中添加α-酮异戊酸（亮氨酸生物合成途径中的第一种化合物）的小鼠，体重继续像缺乏亮氨酸饮食的小鼠一样快速减轻。
