Holaday D A, Fiserova-Bergerova V, Latto I P, Zumbiel M A
Anesthesiology. 1975 Sep;43(3):325-32. doi: 10.1097/00000542-197509000-00009.
Pulmonary and renal excretion of isoflurane and its metabolites was studied in nine surgical patients following administration of known quantitities of isoflurane. Uptake and pulmonary washout were predictable by a mathematical model for inert vapors. The agreement between predicted and experimental data supports the view that isoflurane is subject to little or no biotransformation. The average recovery in exhaled air was 95 per cent, SE 7 per cent. The postoperative increase of urinary excretion of fluoride and organic fluorine accounted for less than 0.2 per cent of fluorine administered as isoflurane. This small extent of biotransformation is probably biologically insignificant, but only after extensive clinical experience can the hazard of delayed toxic response be conclusively evaluated.
在给九名外科手术患者给予已知量的异氟烷后，研究了异氟烷及其代谢产物的肺和肾排泄情况。惰性气体的摄取和肺清除情况可通过数学模型进行预测。预测数据与实验数据之间的一致性支持了异氟烷很少或几乎不发生生物转化的观点。呼出气体中的平均回收率为95%，标准误差为7%。术后尿中氟化物和有机氟排泄量的增加占作为异氟烷给予的氟的不到0.2%。这种小程度的生物转化在生物学上可能无显著意义，但只有在广泛的临床经验之后，才能最终评估延迟毒性反应的危害。
