Courtot D, Mouthon G, Roux L, Jeanin E
Ann Rech Vet. 1975;6(2):117-29.
The practise of repeated doping of the sport horse led us to examine its effects on the health of the animal, and particularly on muscular activity. The main doping agent used at present (acepromazine) has already been studied (COURTOT et al., 1974). In this paper, we study the secondary effects of diazepam, a derivative of the benzodiazepine series, which is being used more and more frequently on horses. In treated animals as compared to controls, we observe: -- a slight respiratory depression related solely to effort, -- an increase in seric creatine phosphokinase rate with no apparent relation to effort. A discussion of these results leads to the conclusion that the secondary effects of diazepam are: -- a punctual effect on respiration as related to decreasing effort intensity, -- a toxic effect on muscle.
对运动马反复使用兴奋剂的做法促使我们研究其对动物健康的影响，尤其是对肌肉活动的影响。目前使用的主要兴奋剂（乙酰丙嗪）已有人研究过（库尔托等人，1974年）。在本文中，我们研究苯二氮䓬类衍生物地西泮的副作用，该药物在马匹上的使用越来越频繁。与对照动物相比，在接受治疗的动物身上，我们观察到：——仅与运动相关的轻微呼吸抑制，——血清肌酸磷酸激酶水平升高，且与运动无明显关系。对这些结果的讨论得出结论，地西泮的副作用是：——与运动强度降低相关的对呼吸的即时影响，——对肌肉的毒性作用。
