Courtot D, Roux L, Mouthon G, Jeanin E
Ann Rech Vet. 1975;6(2):103-16.
Doping with tranquilizers has appeared recently in horse-back riding sports. In this paper we study the effects of acepromazine, one of the main tranquilizers used, on various physiological and biochemical aspects of muscular activity (cardiac and respiratory rhythms, seric rates of glucose, urea, protein, creatine phosphokinase, glutamate oxalacetate transaminase, alkaline phosphatase). A low dose (0.02 mg/kg) of acepromazine is injected; the evolution of the variables is studied before and after a standardized effort. After the effort and during recuperation, acepromazine administration causes: -- a decrease of respiratory rhythm and seric protein rats, -- an increase of creatine phosphokinase rate. A discussion of these results suggests that acepromazine depresses the respiratory centers and has a possible toxic effect on the muscle cell.
使用镇静剂在马术运动中时有发生。本文研究了常用的主要镇静剂之一乙酰丙嗪对肌肉活动的各种生理和生化方面（心脏和呼吸节律、血清葡萄糖、尿素、蛋白质、肌酸磷酸激酶、谷氨酸草酰乙酸转氨酶、碱性磷酸酶水平）的影响。注射低剂量（0.02毫克/千克）的乙酰丙嗪；在标准化运动前后研究各项变量的变化情况。运动后及恢复过程中，给予乙酰丙嗪会导致：——呼吸节律和血清蛋白水平降低，——肌酸磷酸激酶水平升高。对这些结果的讨论表明，乙酰丙嗪会抑制呼吸中枢，并且可能对肌肉细胞产生毒性作用。
