[The movement from the humoral theory of disease to the birth of the modern clinic in Mexico].

This article refers to the time when the "Real y Pontificia Universidad de México" was closed and the Establecimiento de Ciencias Médicas (Medical Sciences Establishment) was created in 1833. Due to this historical event, it was done firstly as an epistemological approach in the history of medicine in Mexico; this is to say, disease concept changed. Instead of the Humoral Theory, the Biological Model regarding the lesion was developed. This model supports that disease is an anatomical or functional disturbance in the human body. The research, theoretically, is based on the philosophy of Gaston Bachelard.