Davila T, Davila D
Arch Int Pharmacodyn Ther. 1975 Jun;215(2):336-44.
Uptake and release of 3H-metaraminol was measured in vitro incubating rat lung tissue in the presence of ouabain (1.5-45 mug/ml), cocaine (1-30 mug/ml), tyramine (0.1-3 mug/ml, reserpine (0.05-1.5 mug/ml), imipramine (0.1-3 mug/ml) and desipramine (0.3-10 mug/ml. All drugs significantly inhibited uptake and release of 3H-metaraminol from lung tissue. This blockade most probably occurs at membrane levels of both neuronal uptake-1 sites and extraneuronal uptake-2 sites. These results further emphasize the importance of the lung in the fate of drugs and endogenous substances.
在哇巴因（1.5 - 45微克/毫升）、可卡因（1 - 30微克/毫升）、酪胺（0.1 - 3微克/毫升）、利血平（0.05 - 1.5微克/毫升）、丙咪嗪（0.1 - 3微克/毫升）和地昔帕明（0.3 - 10微克/毫升）存在的情况下，通过体外孵育大鼠肺组织来测定³H - 间羟胺的摄取和释放。所有药物均显著抑制³H - 间羟胺从肺组织的摄取和释放。这种阻断很可能发生在神经元摄取 - 1位点和神经元外摄取 - 2位点的膜水平。这些结果进一步强调了肺在药物和内源性物质命运中的重要性。
