Gulati O D, Shah N S
Res Commun Chem Pathol Pharmacol. 1977 Mar;16(3):565-8.
Nicotine released 3H-radioactivity from rat hypothalamus labeled with 3H-metaraminol (3H-MA) in a concentration-related manner. The release was not blocked by hexamethonium (1.8 x 10(-5)M - 2.3 x 10(-3)m), tetrodotoxin (3 x 10(-7)M), lidocaine (6 x 10(-5)M or Ca++-free medium. Cocaine (3 x 10(-5)M) blocked the releasing action of nicotine. Nicotine failed to release 3H-MA in tissue exposed to tyramine. It is concluded that the nicotine-induced release of 3H-MA is intracellular.
尼古丁以浓度相关的方式从用³H-间羟胺（³H-MA）标记的大鼠下丘脑释放³H放射性。六甲铵（1.8×10⁻⁵M - 2.3×10⁻³M）、河豚毒素（3×10⁻⁷M）、利多卡因（6×10⁻⁵M）或无钙培养基均不能阻断该释放。可卡因（3×10⁻⁵M）可阻断尼古丁的释放作用。在暴露于酪胺的组织中，尼古丁不能释放³H-MA。由此得出结论，尼古丁诱导的³H-MA释放是细胞内的。
