Lund G K, Wendland M F, Shimakawa A, Arheden H, Ståhlberg F, Higgins C B, Saeed M
Department of Radiology, University of California San Francisco, 505 Parnassus Ave, San Francisco, CA 94143-0628, USA.
Radiology. 2000 Nov;217(2):487-93. doi: 10.1148/radiology.217.2.r00nv10487.
To validate coronary sinus flow measurements for quantification of global left ventricular (LV) perfusion by means of velocity-encoded cine (VEC) magnetic resonance (MR) imaging and flow probes.
Measurements of coronary sinus flow were performed in seven dogs by using VEC MR imaging at baseline, single coronary arterial stenosis, dipyridamole stress, and reactive hyperemia. These measurements were compared with flow probe measurements of coronary blood flow (CBF) in the left anterior descending coronary (LAD) and circumflex (CFX) arteries (CBF(LAD+CFX)) and coronary sinus. LV blood perfusion was calculated in milliliters per minute per gram from coronary sinus flow, and LV mass was obtained by using VEC and cine MR imaging. LV mass was validated at autopsy.
CBF(LAD+CFX) and coronary sinus flow at VEC MR imaging showed close correlation (r = 0.98, P: <.001). The difference between CBF(LAD+CFX) and MR coronary sinus flow was 3.1 mL/min +/- 8.5 (SD). LV mass at cine MR imaging was not significantly different from that at autopsy (73.2 g +/- 12.8 vs 69. 4 g +/- 12.8). At baseline, myocardial perfusion was 0.40 mL/min/g +/- 0.09 at VEC MR imaging, and CBF(LAD+CFX) was 0.44 mL/min/g +/- 0. 08 (not significant). Reactive hyperemia resulted in 2.7- and 2. 3-fold increases in coronary sinus flow at VEC MR imaging and flow probe CBF(LAD+CFX), respectively.
VEC MR imaging has the potential to measure coronary sinus flow during different physiologic conditions and can serve as a noninvasive modality to quantify global LV perfusion in patients.
通过速度编码电影（VEC）磁共振（MR）成像和血流探头验证冠状静脉窦血流测量用于量化左心室（LV）整体灌注的情况。
对7只犬进行冠状静脉窦血流测量，分别在基线、单支冠状动脉狭窄、双嘧达莫负荷试验和反应性充血状态下采用VEC MR成像。将这些测量结果与左前降支冠状动脉（LAD）和回旋支冠状动脉（CFX）（CBF（LAD+CFX））及冠状静脉窦的血流探头测量的冠状动脉血流（CBF）进行比较。根据冠状静脉窦血流计算左心室每分钟每克的血液灌注量，并通过VEC和电影MR成像获得左心室质量。左心室质量在尸检时得到验证。
VEC MR成像时CBF（LAD+CFX）与冠状静脉窦血流显示出密切相关性（r = 0.98，P <.001）。CBF（LAD+CFX）与MR冠状静脉窦血流之间的差异为3.1 mL/min±8.5（标准差）。电影MR成像时的左心室质量与尸检时无显著差异（73.2 g±12.8对69.4 g±12.8）。在基线时，VEC MR成像的心肌灌注为0.40 mL/min/g±0.09，CBF（LAD+CFX）为0.44 mL/min/g±0.08（无显著差异）。反应性充血使VEC MR成像时的冠状静脉窦血流和血流探头测量的CBF（LAD+CFX）分别增加了2.7倍和2.3倍。
VEC MR成像有潜力在不同生理状态下测量冠状静脉窦血流，并可作为一种无创方法来量化患者的左心室整体灌注。
