Balanovskaia E V, Balanovskiĭ O P, Spitsyn V A, Bychkovskaia L S, Makarov S V, Paĭ G V, Subbota D S
Research Center for Medical Genetic, Russian Academy of Medical Sciences, Moscow, 115478 Russia.
Genetika. 2001 Aug;37(8):1138-51.
The study continues the series of works on the Russian gene pool. Gene geographic analysis of five erythrocytic gene markers best studied in the Russian population (ACP1, PGM1, ESD, GLO1, and 6-PGD) has been performed. Gene-geographic electronic maps have been constructed for 13 alleles of these loci and their correlations with geographic latitude and longitude. For all maps, statistical characteristics are presented, including the variation range and mean gene frequencies, partial and multiple correlations with latitude and longitude, and parameters of heterozygosity and interpopulation diversity. The maps of eight alleles (ACP1A, ACP1C, PGM12+, PGM12-, PGM11-, ESD1, GLO11, and PGDC) are shown and analyzed in detail. The genetic relief and structural elements of the maps are compared with the ecumenical trends, main variation patterns of these genes in northern Eurasia, and genetic characteristics of the indigenous populations of the Urals and Europe.
该研究延续了关于俄罗斯基因库的一系列工作。对俄罗斯人群中研究得最为充分的五个红细胞基因标记(ACP1、PGM1、ESD、GLO1和6 - PGD)进行了基因地理分析。已构建了这些基因座的13个等位基因的基因地理电子地图,以及它们与地理纬度和经度的相关性。对于所有地图,均给出了统计特征,包括变异范围和平均基因频率、与纬度和经度的偏相关和复相关,以及杂合度和群体间多样性参数。展示并详细分析了八个等位基因(ACP1A、ACP1C、PGM12 +、PGM12 -、PGM11 -、ESD1、GLO11和PGDC)的地图。将地图的遗传地貌和结构要素与普遍趋势、这些基因在北亚的主要变异模式以及乌拉尔和欧洲原住民的遗传特征进行了比较。