Al-Sheikhly F A, Carlson H C
Avian Dis. 1975 Jul-Sep;19(3):397-407.
Twenty-four 4-week-old poults, free from Mycoplasma meleagridis and M. gallisepticum, were inoculated with a velogenic viscerotropic strain of Newcastle disease virus. Clinical signs (gasping, coughing, and dyspnea) developed 4-5 days postinoculation, continued until nervous derangement appeared, and then (usually 3 days after initial clinical signs appeared) declined in severity. Prominent nervous signs were paresis and paralysis of the extremities, with pronounced head-shaking. The most constant gross lesions detected involved the airsacs. The abdominal sacs of a few poults contained a large accumulation of yellowish, cheesy exudate and there was cloudiness of the thoracic airsacs of all inoculated poults. A few turkeys had tracheitis with some catarrhal exudates and casts in the lower part of the tracheal lumen. Congestion of lepto-meningeal vessels usually correlated with the severity of the nervous signs. The histologic lesions were characterized by both degenerative and proliferative changes with predominantly mononuclear cell and heterophil infiltrations throughout the body. The obvious lesion seen in the recovery stage of the disease was proliferation of lymphofollicular nodules in the parenchymatous organs.
24只4周龄、无火鸡支原体和鸡毒支原体的雏火鸡，接种了新城疫病毒的速发型嗜内脏毒株。接种后4 - 5天出现临床症状（喘气、咳嗽和呼吸困难），持续到出现神经紊乱，然后（通常在最初临床症状出现后3天）症状严重程度下降。突出的神经症状是肢体轻瘫和麻痹，伴有明显的摇头。检测到的最常见的大体病变累及气囊。几只雏火鸡的腹气囊中有大量淡黄色、干酪样渗出物积聚，所有接种雏火鸡的胸气囊均有混浊。一些火鸡有气管炎，气管腔下部有一些卡他性渗出物和管型。软脑膜血管充血通常与神经症状的严重程度相关。组织学病变的特征是变性和增殖性变化，全身主要有单核细胞和异嗜性粒细胞浸润。疾病恢复阶段可见的明显病变是实质器官中淋巴滤泡结节的增殖。
