Abdul-Aziz T A, Arp L H
Avian Dis. 1983 Oct-Dec;27(4):1131-41.
Five-week-old turkeys were exposed by aerosol to the LaSota strain of Newcastle disease virus. Poults were killed on days 2, 4, 6, 8, 10, 12, and 14 postexposure, and tracheas were processed for virus quantitation and histologic examination. Newcastle disease virus was recovered at a high titer from all tracheas collected 2, 4, and 6 days postexposure. The initial tracheal lesion observed on day 2 was swelling of ciliated columnar and mucous gland cells. Some of the affected cells contained intracytoplasmic inclusions. Cell swelling and degeneration were followed by epithelial cell proliferation, fibrinopurulent exudation, and lymphocytic infiltration. Epithelial cell proliferation was most severe on days 4 and 6, when tracheas were lined with several layers of immature cells. Lymphoid nodules appeared on day 6 and persisted up to day 14. From day 8 on, there was regression of the proliferative lesion accompanied by differentiation of the immature epithelium. By day 14, the tracheal mucosa regained its normal histologic appearance.
将5周龄的火鸡通过气溶胶暴露于新城疫病毒LaSota株。在暴露后第2、4、6、8、10、12和14天处死雏鸡，并对气管进行处理以进行病毒定量和组织学检查。在暴露后2、4和6天收集的所有气管中均以高滴度回收了新城疫病毒。在第2天观察到的最初气管病变是纤毛柱状细胞和黏液腺细胞肿胀。一些受影响的细胞含有胞质内包涵体。细胞肿胀和变性之后是上皮细胞增殖、纤维蛋白脓性渗出和淋巴细胞浸润。上皮细胞增殖在第4天和第6天最为严重，此时气管内衬有几层未成熟细胞。淋巴小结在第6天出现并持续到第14天。从第8天开始，增殖性病变消退，同时未成熟上皮发生分化。到第14天，气管黏膜恢复其正常组织学外观。
