Haemoglobin Titusville: alpha94 Asp replaced by Asn. A new haemoglobin with a lowered affinity for oxygen.
作者信息
Schneider R G, Atkins R J, Hosty T S, Tomlin G, Casey R, Lehmann H, Lorkin P A, Nagai K
出版信息
Biochim Biophys Acta. 1975 Aug 19;400(2):365-73.
PMID:1164512
Abstract
A new haemoglobin variant with a decreased oxygen affinity is described, in which the substitution, alpha 94 (G1) Asp replaced by Asn, affects the alpha1beta2 contact alpha1G1-beta2G4. The relevance of this variant to our understanding of the importance of the hydrogen bond between alpha1G1 and beta2G4 in Perutz's model of oxyhaemoglobin A is discussed.
摘要
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