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[鼠疫杆菌I组分的实验性保护作用]

[Experimental protective of fraction I of the plague microbe].

作者信息

Pautov V N, Chicherin Iu V, Evstigneev V I, Byvalov A A, Kedrov O A

出版信息

Zh Mikrobiol Epidemiol Immunobiol. 1979 Oct(10):37-42.

PMID:116458
Abstract

The immunogenic properties of the freeze-dried preparation of fraction I tisolated from the culture of avirulent Pasteurella pestis strain were studied in experiments on hamadryas baboons, guinea-pigs and white mice. The preparation was found to have a pronounced protective effect in hamadryas baboons and white mice, especially when the preparation was used in mixture with incomplete Freund adjuvant. In hamadryas baboons resistance to infection was shown to correlate with hemagglutionation antibody titres.

摘要

对从无毒鼠疫巴氏杆菌菌株培养物中分离出的I组分冻干制剂的免疫原性特性,在阿拉伯狒狒、豚鼠和小白鼠身上进行了实验研究。结果发现该制剂在阿拉伯狒狒和小白鼠身上具有显著的保护作用,尤其是当该制剂与不完全弗氏佐剂混合使用时。在阿拉伯狒狒身上,抗感染能力与血凝抗体滴度相关。

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Pleiotropic effects of the lpxM mutation in Yersinia pestis resulting in modification of the biosynthesis of major immunoreactive antigens.鼠疫耶尔森氏菌中lpxM突变的多效性作用导致主要免疫反应性抗原生物合成的改变。
Vaccine. 2009 Apr 6;27(16):2240-50. doi: 10.1016/j.vaccine.2009.02.020. Epub 2009 Feb 13.
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Intraspecific diversity of Yersinia pestis.
鼠疫耶尔森氏菌的种内多样性。
Clin Microbiol Rev. 2004 Apr;17(2):434-64. doi: 10.1128/CMR.17.2.434-464.2004.
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Fraction 1 capsular antigen (F1) purification from Yersinia pestis CO92 and from an Escherichia coli recombinant strain and efficacy against lethal plague challenge.从鼠疫耶尔森菌CO92和大肠杆菌重组菌株中纯化1型荚膜抗原(F1)及其对致死性鼠疫攻击的疗效。
Infect Immun. 1996 Jun;64(6):2180-7. doi: 10.1128/iai.64.6.2180-2187.1996.