• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

We have a prejudice against ourselves -- sentiment, ethics, and reason.

作者信息

Rosenberg Leo T

出版信息

J Med Humanit. 1993 Spring;14(1):5-14. doi: 10.1007/BF01138156.

DOI:10.1007/BF01138156
PMID:11645807
Abstract

Briefly stated my point is that the well-being of each person in a community conceived abstractly may be all too easily sacrificed for the sake of the abstraction. Physicians may offer critically ill patients places in programs of experimental treatment, but there is commonly a catch to the offer. To take part in a program of clinical experiment a patient must not only risk a possible failure of a fresh drug and the chance of destructive side effects from the drug, but the patients must risk only getting the traditional treatment along with a placebo rather than the experimental drug. Placebo control, double blind critical protocols for testing effects of fresh drugs on critically ill patients are a commonplace. I question the scientific objectivity of the protocols and the underlying ethic, and suggest use of alternate protocols. Experimental tests in the treatment of gram-negative bacteria blood infections, muscular dystrophy, and AIDS and AIDS-related diseases are examples.

摘要

相似文献

1
We have a prejudice against ourselves -- sentiment, ethics, and reason.
J Med Humanit. 1993 Spring;14(1):5-14. doi: 10.1007/BF01138156.
2
Building a new consensus: ethical principles and policies for clinical research on HIV/AIDS.建立新的共识:关于艾滋病毒/艾滋病临床研究的伦理原则与政策
IRB. 1991 Jan-Apr;13(1-2):1-17.
3
The ethics of placebos in AIDS drug trials.
HEC Forum. 1992;4(3):155-62. doi: 10.1007/BF00057868.
4
Community-based AIDS research.基于社区的艾滋病研究。
Eval Rev. 1990 Oct;14(5):502-37. doi: 10.1177/0193841X9001400505.
5
Regulation of drug treatments for HIV and AIDS: a contractarian model of access.
Yale J Regul. 1994 Summer;11(2):401-53.
6
The need for improved access to experimental drug therapy: AIDS activists and their call for a parallel track policy.改善实验性药物治疗可及性的必要性:艾滋病活动人士及其对平行轨道政策的呼吁。
Adm Law J. 1991 Winter;4(3):589-634.
7
Ethics and placebo-controlled thrombolytic trials: the future.
Coron Artery Dis. 1991 Sep;2(7):849-52.
8
The changing clinical trials scene: the role of the IRB.不断变化的临床试验场景:机构审查委员会的作用。
IRB. 1988 Jul-Aug;10(4):1-5.
9
Ethics of drug experimentation.药物实验伦理
Dolentium Hominum. 1987;4(2nd Yr. 1):60-75.
10
Ethical dilemmas with studies in less-developed countries: AIDS research trials.欠发达国家研究中的伦理困境:艾滋病研究试验
IRB. 1991 Jul-Aug;13(4):8-9.

本文引用的文献

1
A critique of pure reason, a passion to survive: cheating on AIDS trials.《纯粹理性批判》,生存的热情:艾滋病试验中的欺诈行为
N Y Times Web. 1990 Oct 21:E4.
2
Myoblast transfer improves muscle genetics/structure/function and normalizes the behavior and life-span of dystrophic mice.成肌细胞移植可改善肌肉的基因/结构/功能,并使营养不良小鼠的行为和寿命恢复正常。
Adv Exp Med Biol. 1990;280:75-84; discussion 84-7. doi: 10.1007/978-1-4684-5865-7_10.
3
Plausible structural/functional/behavioral/biochemical transformations following myoblast transfer therapy.
成肌细胞移植治疗后可能出现的结构/功能/行为/生化转变。
Adv Exp Med Biol. 1990;280:241-9; discussion 249-50. doi: 10.1007/978-1-4684-5865-7_28.
4
Increase in National Hospital Discharge Survey rates for septicemia--United States, 1979-1987.1979 - 1987年美国全国医院出院调查中败血症发病率的上升。
MMWR Morb Mortal Wkly Rep. 1990 Jan 19;39(2):31-4.
5
The safety and pharmacokinetics of GLQ223 in subjects with AIDS and AIDS-related complex: a phase I study.
AIDS. 1990 Dec;4(12):1197-204. doi: 10.1097/00002030-199012000-00003.
6
Treatment of gram-negative bacteremia and septic shock with HA-1A human monoclonal antibody against endotoxin. A randomized, double-blind, placebo-controlled trial. The HA-1A Sepsis Study Group.使用抗内毒素的HA-1A人单克隆抗体治疗革兰氏阴性菌血症和感染性休克。一项随机、双盲、安慰剂对照试验。HA-1A脓毒症研究组。
N Engl J Med. 1991 Feb 14;324(7):429-36. doi: 10.1056/NEJM199102143240701.
7
A controlled clinical trial of E5 murine monoclonal IgM antibody to endotoxin in the treatment of gram-negative sepsis. The XOMA Sepsis Study Group.E5鼠抗内毒素单克隆IgM抗体治疗革兰氏阴性败血症的对照临床试验。XOMA败血症研究小组。
JAMA. 1991 Aug 28;266(8):1097-102.
8
Dystrophin production induced by myoblast transfer therapy in Duchenne muscular dystrophy.杜氏肌营养不良症中成肌细胞移植疗法诱导的抗肌萎缩蛋白生成
Lancet. 1990 Jul 14;336(8707):114-5. doi: 10.1016/0140-6736(90)91628-n.
9
Low-dose co-trimoxazole for prevention of Pneumocystis carinii pneumonia in human immunodeficiency virus disease.
Lancet. 1991 Feb 23;337(8739):468-71. doi: 10.1016/0140-6736(91)93402-u.