6-羟基多巴胺对脑线粒体单胺氧化酶的体外抑制作用。
In vitro inhibition of brain mitochondrial monoamine oxidase by 6-hydroxydopamine.
作者信息
Youdim M B
出版信息
Br J Pharmacol. 1975 Jul;54(3):403-5. doi: 10.1111/j.1476-5381.1975.tb07583.x.
Abstract
6-Hydroxydopamine (6-OHDA) inhibits rat brain mitochondrial monoamine oxidase (MAO) when kynuramine or dopamine are used as substrates. The effect is competitive and reversible giving Ki values of 74 and 176 muM with the respective substrates. At high concentrations (5 mM) of each substrate, inhibition of MAO was not observed.
摘要
当犬尿胺或多巴胺用作底物时，6-羟基多巴胺（6-OHDA）可抑制大鼠脑线粒体单胺氧化酶（MAO）。这种作用是竞争性且可逆的，以各自底物计算的抑制常数（Ki）值分别为74和176μM。在每种底物的高浓度（5 mM）下，未观察到对MAO的抑制作用。
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