铝对脑线粒体单胺氧化酶-A（MAO-A）活性的影响——一项体外动力学研究。
Effect of aluminium (Al) on brain mitochondrial monoamine oxidase-A (MAO-A) activity--an in vitro kinetic study.
作者信息
Rao K S, Rao G V
机构信息
Department of Biochemistry and Nutrition, Central Food Technological Research Institute, Mysore, India.
出版信息
Mol Cell Biochem. 1994 Aug 17;137(1):57-60. doi: 10.1007/BF00926039.
Effect of aluminium (Al) on rat brain mitochondrial monoamine oxidase-A (MAO-A) was studied in vitro at three different pH (4.0, 7.4 and 9.0) values. The results have shown that Al is a non-competitive inhibitor for MAO-A. The data also showed that MAO-A inhibition by Al varies with free Al3+ concentration and different forms of Al under different pH conditions. Al altered the maximum velocity (Vmax) of MAO-A but did not affect substrate-enzyme affinity (Km). Al formed a strong chelation with the substrate (Kynuramine) (1:1).
在体外研究了三种不同pH值（4.0、7.4和9.0）下铝（Al）对大鼠脑线粒体单胺氧化酶A（MAO-A）的影响。结果表明，Al是MAO-A的非竞争性抑制剂。数据还显示，Al对MAO-A的抑制作用随游离Al3+浓度以及不同pH条件下Al的不同形式而变化。Al改变了MAO-A的最大反应速度（Vmax），但不影响底物与酶的亲和力（Km）。Al与底物（犬尿胺）形成了强螯合物（1:1）。
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