Ellis F R, Clarke I M, Modgill M, Currie S, Harriman D G
Br Med J. 1975 Aug 30;3(5982):511-3. doi: 10.1136/bmj.3.5982.511.
Evidence is presented that serum creatinine phosphokinase (CPK) activity is of no direct value in screening patients for susceptibility to malignant hyperpyrexia and does not correlate with halothane-induced muscle contracture or the presence of myopathy. Widely differing CPK values were found at different times in the same people. In most "malignant hyperpyrexia" families the susceptible patients had either normal or inconsistently raised CPK values.
有证据表明,血清肌酸磷酸激酶(CPK)活性在筛查患者对恶性高热的易感性方面没有直接价值,并且与氟烷诱导的肌肉挛缩或肌病的存在无关。在同一人群的不同时间发现了差异很大的CPK值。在大多数“恶性高热”家族中,易感患者的CPK值要么正常,要么不一致地升高。