Martel A, Spigelblatt L, Perreault L, Rosenfeld R
Can Anaesth Soc J. 1979 Jan;26(1):55-7. doi: 10.1007/BF03039455.
Malignant hyperthermia, a life-threatening complication of anaesthesia, occurred in a 5 1/2-year-old girl undergoing dental surgery in a dental clinic. During induction, after 20 mg of succinylcholine, the anaesthetist noted a moderate rigidity of the mandible that did not interfere with the tracheal intubation. However, after 45 minutes, the temperature rose to 38.8 degrees C, pulse was rapid at 160 per minute and the child was slightly cyanosed. The diagnosis of malignant hyperthermia was made (the temperature eventually reached 40.8 degrees C). The child was immediately treated with refrigeration, procainamide and sodium bicarbonate. She was then moved to a hospital centre where the treatment was continued and she recovered completely. After extensive investigation, we found that the paternal grandfather of the child died at age 58, several hours after a bilateral lumbar sympathectomy under general anaesthesia. The cause of the death, as confirmed by hospital records, was malignant hyperthermia. No genetic counselling was given at that time; this omission has since been corrected. Early diagnosis and the availability on the premises of the necessary drugs and equipment to treat such a complication probably saved this child's life. In 1975, "La Corporation Professionnelle des Médecins du Québec" published standards for practice of anaesthesia outside a hospital setting. The compliance of the dental clinic with such standards has contributed to the avoidance of a catastrophe.
恶性高热是一种危及生命的麻醉并发症,发生在一名在牙科诊所接受牙科手术的5岁半女童身上。诱导麻醉期间,在给予20毫克琥珀酰胆碱后,麻醉师注意到下颌中度僵硬,但这并未妨碍气管插管。然而,45分钟后,体温升至38.8摄氏度,脉搏快速,每分钟160次,患儿略有发绀。确诊为恶性高热(体温最终达到40.8摄氏度)。患儿立即接受了降温、普鲁卡因胺和碳酸氢钠治疗。随后她被转至一家医院中心,在那里继续接受治疗并完全康复。经过广泛调查,我们发现患儿的祖父在58岁时,在全身麻醉下进行双侧腰交感神经切除术后数小时死亡。医院记录证实,死亡原因是恶性高热。当时未进行遗传咨询;这一疏忽后来已得到纠正。早期诊断以及诊所具备治疗此类并发症所需的药物和设备,可能挽救了这名患儿的生命。1975年,“魁北克医生职业协会”发布了医院外麻醉操作标准。牙科诊所遵守这些标准有助于避免一场灾难。