Safer D J, Allen R P
Dis Nerv Syst. 1975 Aug;36(8):454-7.
The characteristics and classroom behavior changes of hyperactive (HA) school children treated with stimulants during the years, 1969-1974, were evaluated in relation to the age of the child. Fourteen children who began taking stimulants before age 8 were compared to 11 who were initiated on stimulant treatment at age 13-16. Next, 13 children who continued on stimulants into their teens were studied to compare their pre-teen with their teenage drug response. The major findings were: 1) The therapeutic response of stimulants for hyperactivity did not significantly change from age 6 to age 16. 2) Pre-treatment teacher ratings indicated that as a group, teenage HA children were as inattentive as younger HA children, but less aggressive and overactive. 3) The mean dose of stimulant medication to achieve a successful classroom response for school age HA children did not significantly increase with age. 4) Parental resistances to stimulants were not related to the age of the HA child, but behavioral resistances by the child increased significantly during the teens. 5) There were no reports of abuse of stimulants by HA teenagers.
1969年至1974年间，对使用兴奋剂治疗的多动（HA）学龄儿童的特征和课堂行为变化与儿童年龄的关系进行了评估。将14名8岁前开始使用兴奋剂的儿童与11名13至16岁开始接受兴奋剂治疗的儿童进行了比较。接下来，对13名持续使用兴奋剂至青少年期的儿童进行了研究，以比较他们在青春期前和青少年期对药物的反应。主要发现如下：1）从6岁到16岁，兴奋剂对多动的治疗反应没有显著变化。2）治疗前教师的评分表明，总体而言，青少年HA儿童与年幼的HA儿童一样注意力不集中，但攻击性和多动程度较低。3）学龄期HA儿童在课堂上取得成功反应所需的兴奋剂平均剂量不会随着年龄的增长而显著增加。4）父母对兴奋剂的抵触与HA儿童的年龄无关，但儿童在青少年期的行为抵触显著增加。5）没有关于HA青少年滥用兴奋剂的报告。
