Grisorixin, an ionophorous antibiotic of the nigericin group. II. Chemical and structural study of grisorixin and some derivatives.

Grisorixin, a polycyclic polyether antibiotic of the nigericin group, showed ionophorous properties. The conformations of crystallized grisorixin and its metallic salts are very similar and are compared in this paper. The physico-chemical properties of the salts are described. The chemical oxidation of grisorixin methyl ester allowed us to isolate several oxidation products whose structures are described.