Harbert G M, Croft B Y, Spisso K R
Am J Obstet Gynecol. 1979 Dec 1;135(7):828-42. doi: 10.1016/0002-9378(79)90810-x.
Ten rhesus monkeys were studied between 143 and 161 days of gestation. The unanesthetized animals were confined to restraining chairs and maintained in a controlled environment with continuous monitoring of spontaneous uterine dynamics. Forty-five determinations of blood flow distribution were made using radionuclide-labeled microspheres. The microsphere injections confirmed a circadian pattern of uterine blood flow. These biorhythms are related to alterations in distribution of blood flow to placental and nonplacental portions of the uterus. Myometrial blood flow is highest during the period of light. It is correlated positively to aortic blood pressure (r = 0.490, p less than 0.05) and inversely to uterine artery blood flow (r = -0.508, p less than 0.05). Placental blood flow is highest during the period of darkness. The flow rates are significantly correlated to intra-amniotic pressure (r = -0.602, p less than 0.05) but not to aortic blood pressure (r = -0.185, p less than 0.05). The data indicate that blood flow distribution in the primate uterus is modulated by factors in addition to physiologic pressure-flow relationships. Extrapolation to the human has potential significance.
对10只妊娠143至161天的恒河猴进行了研究。未麻醉的动物被限制在约束椅上，并置于可控环境中，持续监测自发性子宫动态。使用放射性核素标记的微球进行了45次血流分布测定。微球注射证实了子宫血流的昼夜节律模式。这些生物节律与子宫胎盘和非胎盘部分血流分布的改变有关。子宫肌层血流在光照期间最高。它与主动脉血压呈正相关（r = 0.490，p < 0.05），与子宫动脉血流呈负相关（r = -0.508，p < 0.05）。胎盘血流在黑暗期间最高。流速与羊膜腔内压力显著相关（r = -0.602，p < 0.05），但与主动脉血压无关（r = -0.185，p < 0.05）。数据表明，灵长类子宫内的血流分布除了受生理压力-血流关系的影响外，还受其他因素的调节。外推至人类具有潜在意义。
