Rencricca N J, Morse B S, Monette F C, Howard D, Stohlman F
Proc Soc Exp Biol Med. 1975 Sep;149(4):1052-4. doi: 10.3181/00379727-149-38956.
Hydroxyurea, a cytotoxic agent which destroys cells in DNA synthesis, has been shown to evoke the differentiation of a small number of hemopoietic precursor cells in the erythroid series of erythropoietically suppressed hypertransfused mice. This effect does not appear to be mediated by erythropoietin (EP) since the simultaneous injection of anti-EP did not alter this response.
羟基脲是一种细胞毒性药物，可破坏DNA合成过程中的细胞。研究表明，它能促使红细胞生成受抑制且输血过多的小鼠红系中的少量造血前体细胞分化。这种效应似乎不是由促红细胞生成素（EP）介导的，因为同时注射抗EP并未改变这种反应。
