Ben-Ishay Z, Reichert F, Sharon S
Experientia. 1978 Oct 15;34(10):1369-70. doi: 10.1007/BF01981479.
Eradication of replicating bone marrow cells of rat by means of combined administration of single doses of hydroxyurea and vinblastin is followed within 9--10 h by an inflow of lymphoid cells of extramedullary origin in the range of 13,200,000/femur. The rat bone marrow with a high content of lymphoid cells was previously shown to be concentrated in stem cells. The factor(s) which convey the 'information' of decrease of replicating marrow cells to extramedullary sites is at present unknown.
通过联合单次给予羟基脲和长春碱来根除大鼠复制性骨髓细胞后，在9 - 10小时内，有1320万个/股骨的髓外来源淋巴细胞流入。先前已表明，淋巴细胞含量高的大鼠骨髓集中在干细胞中。目前尚不清楚将复制性骨髓细胞减少的“信息”传递到髓外部位的因素。
