成年雄性大鼠体内3H-睾酮的代谢：雌激素给药的影响。

In vivo metabolism of 3H-testosterone in adult male rats: effects of estrogen administration.

作者信息

Lee D K, Bird C E, Clark A F

出版信息

Steroids. 1975 Jul;26(1):137-47. doi: 10.1016/0039-128x(75)90011-2.

DOI:10.1016/0039-128x(75)90011-2

Abstract

The metabolism of testosterone (T) was studied in normal adult male rats using a constant infusion of trace amounts of the 3H-steroid into a tail vein for 3 h in order to attain a state of equilibrium. Samples of plasma, liver, kidney, prostate, seminal vesicles and muscle were analysed for 3H-testosterone, 3H-5alpha-dihydrotestosterone (5alphaDHT) and 3H-5alpha-androstanediol (Adiol). When compared to the 3H-T level in plasma there were high levels of 3H-T in kidney and of 3H-5alphaDHT in prostate and seminal vesicles. Intraperitoneal estradiol valerate administration (100 mug/day) for 4 days decreased and 3H-5alphaDHT levels in the prostate and seminal vesicles. The estrogen administration increased the T metabolic clearance rate from 17.5 1/24 h/100 g body wt to 22.6 1/24 h/100 g body wt.

摘要

利用微量³H标记类固醇持续3小时尾静脉输注的方法，在正常成年雄性大鼠中研究睾酮（T）的代谢，以达到平衡状态。分析血浆、肝脏、肾脏、前列腺、精囊和肌肉样本中的³H睾酮、³H-5α-双氢睾酮（5αDHT）和³H-5α-雄烷二醇（Adiol）。与血浆中的³H-T水平相比，肾脏中³H-T水平较高，前列腺和精囊中³H-5αDHT水平较高。腹腔注射戊酸雌二醇（100μg/天）4天可降低前列腺和精囊中³H-5αDHT水平。雌激素给药使T的代谢清除率从17.5升/24小时/100克体重增加到22.6升/24小时/100克体重。

相似文献

1

In vivo metabolism of 3H-testosterone in adult male rats: effects of estrogen administration.成年雄性大鼠体内3H-睾酮的代谢：雌激素给药的影响。

Steroids. 1975 Jul;26(1):137-47. doi: 10.1016/0039-128x(75)90011-2.

2

Kinetics of (1,2-3H)-testosterone metabolism in normal adult male rats: effects of estrogen administration.正常成年雄性大鼠中（1,2 - 3H）-睾酮代谢的动力学：雌激素给药的影响。

J Steroid Biochem. 1974 Feb;5(1):27-32. doi: 10.1016/0022-4731(74)90024-7.

3

Binding and metabolism of 5alpha-androstane-3alpha, 17 beta-diol and of 5alpha-androstane-3beta, 17 beta-diol in the prostate, seminal vesicles and plasma of male rats: studies in vivo and in vitro.5α-雄甾烷-3α,17β-二醇和5α-雄甾烷-3β,17β-二醇在雄性大鼠前列腺、精囊和血浆中的结合与代谢：体内和体外研究

J Endocrinol. 1975 Mar;64(3):529-38. doi: 10.1677/joe.0.0640529.

4

In vivo metabolism of 3H-dihydrotestosterone and 3H-androstanediol in adult male rats.成年雄性大鼠体内3H-二氢睾酮和3H-雄烷二醇的代谢

J Steroid Biochem. 1975 Nov-Dec;6(11-12):1549-54. doi: 10.1016/0022-4731(75)90213-7.

5

Kinetics of in vivo 5 alpha-androstane-3 beta, 17 beta-diol metabolism in adult normal and castrated male rats.

J Steroid Biochem. 1981 Feb;14(2):199-203. doi: 10.1016/0022-4731(81)90174-6.

6

In vitro conversion of 5alpha-reduced metabolites of testosterone by the seminal vesicles, ventral prostate glands and testes of adult rats.成年大鼠精囊、腹侧前列腺和睾丸对睾酮5α-还原代谢产物的体外转化

Steroids. 1978 Feb;31(2):259-67. doi: 10.1016/0039-128x(78)90118-6.

7

Metabolism and mode of action of androgens in target tissues of male rats. V. Uptake and metabolism of cyproterone acetate and its influence on the uptake and metabolism of testosterone and 5alpha-dihydrotestosterone in target organs and peripheral tissues.雄性大鼠靶组织中雄激素的代谢及作用方式。V. 醋酸环丙孕酮的摄取与代谢及其对靶器官和外周组织中睾酮及5α-双氢睾酮摄取与代谢的影响。

Acta Endocrinol (Copenh). 1975 Nov;80(3):592-602.

8

Detection of (3H)5 alpha-androstane-3 alpha,17 beta-diol and 3H17 beta hydroxy-5 alpha-androstan-3-one in mouse testes following administration of (3H) testosterone.给予（3H）睾酮后小鼠睾丸中（3H）5α-雄甾烷-3α，17β-二醇和3H 17β-羟基-5α-雄甾烷-3-酮的检测。

Acta Endocrinol (Copenh). 1973 Sep;74(1):177-85.

9

Metabolism of testosterone in the human prostate and seminal vesicles.睾酮在人前列腺和精囊中的代谢。

Scand J Urol Nephrol. 1977;11(1):1-6. doi: 10.3109/00365597709179684.

10

Effect of neonatal estrogenization on testosterone metabolism in the prostate and in the epididymis of the rat.新生期雌激素化对大鼠前列腺和附睾中睾酮代谢的影响。

J Steroid Biochem. 1989 Mar;32(3):459-65. doi: 10.1016/0022-4731(89)90222-7.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

文档翻译

学术文献翻译模型，支持多种主流文档格式。