Howard C F
Atherosclerosis. 1979 Aug;33(4):479-93. doi: 10.1016/0021-9150(79)90039-x.
Aortic atherosclerosis is minimal in normal Macaca nigra; development of atherosclerosis correlates with increasing severity of diabetes mellitus. The extent of aortic involvement (plaque plus sudanophilia) was quantified and compared with metabolic and clinical parameters. Increasing atherosclerosis correlated with decreasing ability to clear glucose in a tolerance test (P less than 0.01), decreasing insulin (P = 0.02), and increasing glucose (P less than 0.01) and triglycerides (P less than 0.01). A diabetic index, established as a summation of several metabolic measurements, correlated with atherosclerosis at P less than 0.001. On the average, involvement of the thoracic aorta was about 3-fold greater than in the abdominal portion; involvement reached over 40% in severely diabetic monkeys. Atherosclerosis development is unique in these monkeys since they consume a natural ration low in fat and cholesterol. Serum cholesterol did not correlate with diabetes or artherosclerosis. Increasing age alone was associated with slight sudanophila, some intima-media thickening, and occasional small lesions. However, only with increasing severity of diabetes was there significant atherosclerosis.
在正常的黑冠猕猴中，主动脉粥样硬化程度较轻；动脉粥样硬化的发展与糖尿病严重程度的增加相关。对主动脉受累程度（斑块加嗜苏丹性）进行量化，并与代谢和临床参数进行比较。动脉粥样硬化程度增加与糖耐量试验中葡萄糖清除能力下降（P<0.01）、胰岛素水平降低（P = 0.02）、血糖升高（P<0.01）和甘油三酯升高（P<0.01）相关。作为几种代谢测量值总和建立的糖尿病指数与动脉粥样硬化的相关性为P<0.001。平均而言，胸主动脉的受累程度约为腹主动脉的3倍；在重度糖尿病猴中，受累程度超过40%。这些猴子的动脉粥样硬化发展具有独特性，因为它们食用的天然食物中脂肪和胆固醇含量低。血清胆固醇与糖尿病或动脉粥样硬化无关。仅年龄增长与轻微嗜苏丹性、一些内膜中层增厚以及偶尔的小病变有关。然而，只有随着糖尿病严重程度的增加才会出现明显的动脉粥样硬化。
