Byrd K E, Sheskin T A
Department of Anatomy & Cell Biology, Indiana University School of Medicine, Indianapolis 46202-5120, USA.
J Dent Res. 2001 Aug;80(8):1730-5. doi: 10.1177/00220345010800081001.
Although the role of serotonin (5-hydroxytryptamine or 5-HT) in pre-natal craniofacial growth and development has been studied, no research has been done on the effects of serotonin on post-natal craniofacial growth and development. The following experimental question was tested: What effect does increasing in vivo serotonin levels adjacent to trigeminal motoneurons have on post-natal craniofacial structures in young, actively growing rats? Forty male Sprague-Dawley rats were divided into 4 experimental groups (10% serotonin microspheres, 15% serotonin microspheres, blank microspheres, sham surgeries) and underwent stereotactic neurosurgery at post-natal day 35; 5 rats of each group were killed at 14 and 21 post-surgical days for data collection. Statistical analyses by mixed-model, 4 x 2 repeated-measures ANOVA, and post hoc Fisher LSD tests revealed significant (P < or = 0.05, 0.01) differences between groups and sides for muscle weight, cranial dimension, and TMJ dimension data. Data described here indicate that significant alterations of post-natal craniofacial structures can be caused by altered in vivo levels of serotonin adjacent to trigeminal motoneurons.
尽管血清素（5-羟色胺或5-HT）在产前颅面生长发育中的作用已得到研究，但关于血清素对产后颅面生长发育的影响尚无研究。以下实验问题得到了验证：在年轻、处于活跃生长阶段的大鼠中，提高三叉神经运动神经元附近的体内血清素水平对其产后颅面结构有何影响？40只雄性Sprague-Dawley大鼠被分为4个实验组（10%血清素微球组、15%血清素微球组、空白微球组、假手术组），并在出生后第35天接受立体定向神经外科手术；每组5只大鼠在术后第14天和第21天处死以收集数据。通过混合模型、4×2重复测量方差分析以及事后Fisher LSD检验进行的统计分析显示，肌肉重量、颅骨尺寸和颞下颌关节尺寸数据在组间和两侧存在显著（P≤0.05，0.01）差异。此处描述的数据表明，三叉神经运动神经元附近体内血清素水平的改变可导致产后颅面结构的显著改变。
