Ludwig H, Kuzmits R, Pietschmann H, Müller M M
Blut. 1979 Nov;39(5):309-15. doi: 10.1007/BF01014193.
Activities of adenosine deaminase (ADA), adenosine kinase (AK), adenine phosphoribosyltransferase (APRT), hypoxanthine guanine phosphoribosyltransferase (HGPRT), and purine nucleoside phosphorylase (PNP), all enzymes of the purine interconversion system, were determined in lymphocytes of 25 patients with chronic lymphatic leukemia (CLL) and in 23 controls. A statistically significant decrease of PNP activities and a reduction of ADA activities at borderline levels were found in the patients, whereas for the other enzymes assayed no deviation from normal values was observed.
在25例慢性淋巴细胞白血病（CLL）患者及23名对照者的淋巴细胞中，对嘌呤相互转化系统的所有酶，即腺苷脱氨酶（ADA）、腺苷激酶（AK）、腺嘌呤磷酸核糖转移酶（APRT）、次黄嘌呤鸟嘌呤磷酸核糖转移酶（HGPRT）和嘌呤核苷磷酸化酶（PNP）的活性进行了测定。结果发现，患者的PNP活性有统计学意义的降低，ADA活性在临界水平有所下降，而对于所检测的其他酶，未观察到与正常值有偏差。
