Mikhaĭlov V P, Gusikhina V I
Arkh Anat Gistol Embriol. 1975 Aug;69(8):10-6.
Under study were the popliteal lymph nodes of rats at different times after total irradiation of animals (the 1st series), total irradiation with screening the left node (the 2nd series) and local screening of other parts of the body (the 3rd series). X-ray irradiation in all experiments was performed under standard conditions in dosage of 800 r. The amount of mitoses (MC 0/00) in light centers and cortical substance was counted in addition to histological alterations. In shielded lymph nodes (2nd series) mediate effects of irradiation were observed characterized by a decrease of the MK amount and massive death of lymphocytes in later terms than after direct effects (1st series). In irradiated nodes (3rd series) the reparative process was more rapid than in the first series due to migration of lymphocytes from non-irradiated parts of the body. The mediate effect of radiation results also in increased amount of plasma cells in lymphatic nodes of animals subjected to total irradiation (1st and 2nd series). It is suggested by the absence of such increase of amount of plasma cells in locally irradiated lymphatic nodes when screening other parts of the body (3rd series). availability of individual distinctions in the character of the lymphoid tissue response to effects of ionizing radiation puts a question of division of experimental animals at least into 2 subgroups which have different indices of proliferative processes.
研究了动物全身照射后不同时间大鼠的腘淋巴结（第1组）、左侧淋巴结屏蔽下的全身照射（第2组）以及身体其他部位的局部屏蔽照射（第3组）。在所有实验中，X射线照射均在标准条件下以800伦琴的剂量进行。除了组织学改变外，还对亮区和皮质物质中的有丝分裂数量（MC 0/00）进行了计数。在屏蔽淋巴结（第2组）中观察到了辐射的间接效应，其特征是有丝分裂数量减少，淋巴细胞大量死亡，且发生时间比直接照射后（第1组）更晚。在照射的淋巴结（第3组）中，由于淋巴细胞从身体未照射部位迁移，修复过程比第1组更快。辐射的间接效应还导致全身照射的动物（第1组和第2组）淋巴结中的浆细胞数量增加。当屏蔽身体其他部位进行局部照射时（第3组），局部照射的淋巴结中浆细胞数量没有这种增加，这表明淋巴细胞组织对电离辐射效应的反应特征存在个体差异，这就提出了至少将实验动物分为两个具有不同增殖过程指标的亚组的问题。
