Burge J S
Proc R Soc Med. 1975 Feb;68(2):77-9. doi: 10.1177/003591577506800205.
Clinical radiation in man is shown to have similar effects to single dose irradiation in animals. While it is not possible by examining individual nodes to estimate the dose of radiation they have received, progressive changes with increasing doses can be seen leading to loss of lymphoid tissue and replacement by fibrous tissue. Functional changes probably occur, leading to loss of the filtering power of the nodes and their by-pass by anatomotic lymph channels. The purpose of this paper is in no way an appeal to discard radiation as a form of treatment for cancer. The destructive effects of radiation have been known form some time, but the significance of the regional nodes in the immune response to tumour has only recently been considered. A reappraisal is required of the way radiation therapy is given, so that as much as possbile of the immune mechanism may be left undamaged.
临床研究表明，人体接受的辐射与动物接受单剂量辐射具有相似的效果。虽然通过检查单个淋巴结无法估计它们所接受的辐射剂量，但随着剂量增加会出现渐进性变化，导致淋巴组织丧失并被纤维组织取代。可能会发生功能变化，导致淋巴结过滤能力丧失以及解剖学淋巴通道绕过它们。本文的目的绝不是呼吁摒弃放射疗法作为一种癌症治疗方式。辐射的破坏作用早已为人所知，但区域淋巴结在肿瘤免疫反应中的重要性直到最近才被考虑。需要重新评估放射治疗的方式，以便尽可能使免疫机制免受损害。
