二茂钛催化内酯还原为内醇
Titanocene-Catalyzed Reduction of Lactones to Lactols.
作者信息
Verdaguer Xavier, Hansen Marcus C., Berk Scott C., Buchwald Stephen L.
机构信息
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139.
出版信息
J Org Chem. 1997 Nov 28;62(24):8522-8528. doi: 10.1021/jo971560s.
PMID:11671995
Abstract
A convenient method for the conversion of lactones to lactols is described. The hydrosilylation to lactols is carried out via air-stable titanocene difluoride or a titanocene diphenoxide precatalyst using inexpensive polymethylhydrosiloxane (PMHS) as the stoichiometric reductant. These procedures have been demonstrated with a variety of substrates and proceed in good to excellent yield.
摘要
本文描述了一种将内酯转化为内醇的简便方法。使用廉价的聚甲基氢硅氧烷（PMHS）作为化学计量还原剂，通过空气稳定的二氟二茂钛或二苯氧基二茂钛预催化剂进行内酯的硅氢化反应生成内醇。这些方法已在多种底物上得到验证，产率良好至优异。
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