Boncinelli E, Morgan R
Molecular Biology of Development, DIBIT, Instituto Scientifico H San Raffaele, via Olgettina, 58, 20132, Milan, Italy.
Trends Genet. 2001 Nov;17(11):633-6. doi: 10.1016/s0168-9525(01)02418-0.
Otx2 is a member of a highly conserved family of homeodomain-containing transcription factors that function in early brain development. Recent studies have identified a significant number of target genes downstream of Otx2, allowing us to address the question of how it fulfils its diverse developmental roles. Interestingly, many of these target genes are not transcription factors or signaling molecules, and they probably have no direct affect on gene expression. Furthermore, there is evidence that Otx2 coordinates the activity of unrelated genes that have overlapping functions, and that it does so directly without intermediate transcriptional or signaling activity.
Otx2是一个高度保守的含同源结构域转录因子家族的成员，在早期脑发育中发挥作用。最近的研究已经确定了大量位于Otx2下游的靶基因，这使我们能够解决它如何履行其多样的发育作用这一问题。有趣的是，这些靶基因中的许多并非转录因子或信号分子，并且它们可能对基因表达没有直接影响。此外，有证据表明，Otx2协调具有重叠功能的不相关基因的活性，并且它直接这样做，无需中间转录或信号活性。
