Cloft H J, Samuels O B, Tong F C, Dion J E
Department of Radiology, Emory University Hospital, Atlanta, GA 30322, USA.
AJNR Am J Neuroradiol. 2001 Oct;22(9):1764-7.
We describe four cases in which abciximab was used as a thrombolytic rescue agent in the setting of thrombotic events complicating interventional neuroradiologic procedures. After IV administration of abciximab, the thrombus resolved within 30 min in three cases, whereas no thrombolysis occurred in the fourth case despite the addition of intraarterial tissue plasminogen activator. Further evaluation of glycoprotein IIb-IIIa inhibitors in patients with cerebral thromboembolic events is necessary to prove clinical efficacy.
我们描述了4例在介入神经放射学手术并发血栓形成事件时使用阿昔单抗作为溶栓抢救药物的病例。静脉注射阿昔单抗后，3例患者的血栓在30分钟内溶解，而第4例患者尽管加用了动脉内组织纤溶酶原激活剂仍未发生溶栓。有必要对脑栓塞事件患者的糖蛋白IIb-IIIa抑制剂进行进一步评估以证明其临床疗效。
