Bahceciler N N, Arikan C, Akkoc T, Barlan I B
Marmara University Hospital, Pediatric Allergy and Immunology Division, Istanbul, Turkey.
Am J Respir Crit Care Med. 2001 Oct 1;164(7):1150-3. doi: 10.1164/ajrccm.164.7.2101144.
Bronchial hyperreactivity (BHR) is a common characteristic of asthma and is shown to be a risk factor in the development and outcome of asthma. In this study, we aimed to assess the risk factors at referral for the severity of BHR, which was determined at the end of a mean of 3 yr of follow-up in 98 children with asthma [mean (+/- SD) age, 11.0 (+/- 3.4) yr, male/female = 50/48]. We also evaluated the cross-sectional risk factors for the severity of BHR in the observed children. Information on risk factors at referral was collected from the computer records of the patients followed by an end-of-study visit. Lung function, skin-prick, and bronchial provocation tests were done and total serum IgE level was measured on this visit. The relationship between BHR and risk factors was investigated by multiple linear regression analysis. A lower level of FEV1 % at referral was found to be an important predictor of more severe BHR at the end of the follow-up. None of the other risk factors evaluated predicted the severity of current BHR. We concluded that decreased lung function at referral is associated with a more severe BHR determined at the end of a 3-yr follow-up in children with asthma.
支气管高反应性（BHR）是哮喘的一个常见特征，并且已被证明是哮喘发生发展及预后的一个危险因素。在本研究中，我们旨在评估98例哮喘儿童（平均年龄[±标准差]为11.0[±3.4]岁，男/女 = 50/48）在转诊时与随访3年结束时所确定的BHR严重程度相关的危险因素。我们还评估了观察到的儿童中BHR严重程度的横断面危险因素。在研究结束时进行访视前，从患者的计算机记录中收集转诊时的危险因素信息。此次访视时进行了肺功能、皮肤点刺和支气管激发试验，并测定了总血清IgE水平。通过多元线性回归分析研究BHR与危险因素之间的关系。结果发现，转诊时较低的第一秒用力呼气容积百分比（FEV1%）是随访结束时更严重BHR的一个重要预测指标。所评估的其他危险因素均不能预测当前BHR的严重程度。我们得出结论，在哮喘儿童中，转诊时肺功能下降与随访3年结束时所确定的更严重BHR相关。
