Kubo K, Mennin S P, Gorski R A
Endocrinology. 1975 Feb;96(2):492-500. doi: 10.1210/endo-96-2-492.
Because of conflicting data in the literature, the ovulatory response to electrochemical stimulation (ECS) of the medial septal-preoptic complex was measured in pentobarbital-treated normal proestrous and androgenized female rets. Increasing the stimulus strength increases the incidence of ovulation in normal but not in androgenized rats. However, since the ovaries of androgenized rats are relatively insensitive to LH, whereas pituitary responsiveness to LH-releasing factor is normal, the response to ECS was further evaluated in terms of plasma LH. Immunoassayable plasma LH was significantly elevated 30 min after stimulation. Peak LH levels occurred 90 min after stimulation and were returning toward baseline after 120 min. There was no difference in mean plasma LH values in normal and androgenized rats at any time. Stimulation of the diagonal band of Broca, medial septum or medial preoptic area elicited similar plasma LH responses in both groups. These results indicate that the responsiveness of the medial septal-preoptic complex to ECS is not deleteriously affected by neonatal androgen treatment.
由于文献中的数据相互矛盾，于是对戊巴比妥处理的正常动情前期和雄激素化雌性大鼠中隔前视复合物的电化学刺激（ECS）的排卵反应进行了测量。增加刺激强度会增加正常大鼠的排卵发生率，但不会增加雄激素化大鼠的排卵发生率。然而，由于雄激素化大鼠的卵巢对促黄体生成素（LH）相对不敏感，而垂体对促黄体生成素释放因子的反应正常，因此根据血浆LH进一步评估了对ECS的反应。刺激后30分钟，可免疫测定的血浆LH显著升高。LH峰值出现在刺激后90分钟，并在120分钟后恢复到基线水平。在任何时候，正常大鼠和雄激素化大鼠的平均血浆LH值均无差异。刺激布洛卡斜带、中隔或视前内侧区在两组中引起相似的血浆LH反应。这些结果表明，新生期雄激素处理不会对中隔前视复合物对ECS的反应产生有害影响。
