Rutter J M, Beer R J
Infect Immun. 1975 Feb;11(2):395-404. doi: 10.1128/iai.11.2.395-404.1975.
The role of the microbial flora of the large intestine in experimental Trichuris suis infection was studied by comparing the clinical syndrome in conventionally reared (CR) pigs, specific pathogen-free pigs, and gnotobiotic pigs. Thedisease in CR pigs was characterized by a severe mucohemorrhagic enteritis; in contrast, a mild catarrhal enteritis was observed in specific pathogen-free and gnotobiotic pigs. Spirochaetes and vibrio-like organisms were observed only in CR pigs and increased during the clinical phase of the disease. The clinical syndrome was not transmitted by oral administration of intestinal or fecal material from infected CR pigs to CR pigs free of T. suis. Smaller numbers of T. suis produced diarrhea in CR pigs and significantly reduced the growth rates of infected animals; clinical signs and the reduction in growth rate was prevented by incorporating an antibacterial substance (dimetridazole) in the food. Although clinical trichuriasis closely resembles swin dysentery, the two syndromes seem to be distinct. The present results suggest that a microbial component acts synergistically with T. suis to produce the severe clinical syndrome in CR pigs, but identification of the microbial component and the mechanism by which clinical signs are produced await further studies of the bacterial flora of the large intestine of pigs.
通过比较常规饲养（CR）猪、无特定病原体猪和悉生猪的临床症状，研究了大肠微生物群落在实验性猪鞭虫感染中的作用。CR猪的疾病特征为严重的黏液出血性肠炎；相比之下，在无特定病原体猪和悉生猪中观察到的是轻度卡他性肠炎。仅在CR猪中观察到螺旋体和类弧菌，且在疾病临床阶段数量增加。将感染的CR猪的肠道或粪便物质口服给未感染猪鞭虫的CR猪，并未传播临床症状。较少数量的猪鞭虫在CR猪中引起腹泻，并显著降低感染动物的生长速度；通过在食物中添加抗菌物质（二甲硝唑）可预防临床症状和生长速度的降低。尽管临床鞭虫病与猪痢疾非常相似，但这两种综合征似乎是不同的。目前的结果表明，微生物成分与猪鞭虫协同作用，在CR猪中产生严重的临床综合征，但微生物成分的鉴定以及产生临床症状的机制仍有待对猪大肠菌群进行进一步研究。
