猪痢疾：用猪痢疾密螺旋体、大肠弧菌和消化链球菌接种无菌猪。

Brandenburg A C, Miniats O P, Geissinger H D, Ewert E

Can J Comp Med. 1977 Jul;41(3):294-301.

Pure cultures of Treponema hyodysenteriae given orally to conventional pigs resulted in the development of swine dysentery, whereas identical cultures given to gnotobiotic pigs did not produce the disease. Oral inoculation of gnotobiotic pigs with Vibrio coli and/or a peptostreptococcus in addition to T. hyodysenteriae did not result in dysentery. Neutralization of gastric secretions with NaHCO3 immediately prior to inoculation with T. hyodysenteriae increased the period during which treponemes were evident in the feces, as did the inoculation of this organism via the intracecal route. None of the gnotobiotic pigs with a persistent fecal Treponema population developed signs of dysentery. Factors other than those investigated in this work must play a part in the etiology of swine dysentery.

给常规猪口服猪痢疾密螺旋体纯培养物会导致猪痢疾的发生，而给无菌猪接种相同的培养物则不会引发该病。除猪痢疾密螺旋体外，给无菌猪口服结肠弯曲杆菌和/或消化链球菌不会导致痢疾。在用猪痢疾密螺旋体接种前立即用碳酸氢钠中和胃分泌物，可延长粪便中密螺旋体明显可见的时间，通过盲肠内途径接种该菌也有同样效果。没有一头粪便中持续存在密螺旋体的无菌猪出现痢疾症状。在猪痢疾的病因中，必定还有其他未在本研究中调查的因素在起作用。