自主神经系统活动较高的HIV感染者对高效抗逆转录病毒疗法（HAART）反应受损。
Impaired response to HAART in HIV-infected individuals with high autonomic nervous system activity.
作者信息
Cole S W, Naliboff B D, Kemeny M E, Griswold M P, Fahey J L, Zack J A
机构信息
Department of Medicine, University of California, Los Angeles, CA 90095, USA.
出版信息
Proc Natl Acad Sci U S A. 2001 Oct 23;98(22):12695-700. doi: 10.1073/pnas.221134198.
Abstract
Neurotransmitters can accelerate HIV-1 replication in vitro, leading us to examine whether differences in autonomic nervous system (ANS) activity might promote residual HIV-1 replication in patients treated with highly active antiretroviral therapy. Patients who showed constitutively high levels of ANS activity before highly active antiretroviral therapy experienced poorer suppression of plasma viral load and poorer CD4(+) T cell recovery over 3-11 months of therapy. ANS activity was not related to demographic or behavioral characteristics that might influence pathogenesis. However, the ANS neurotransmitter norepinephrine enhanced replication of both CCR5- and CXCR4-tropic strains of HIV-1 in vitro via chemokine receptor up-regulation and enhanced viral gene expression, suggesting that neural activity may directly promote residual viral replication.
摘要
神经递质在体外可加速HIV-1复制，这促使我们研究自主神经系统（ANS）活动的差异是否可能促进接受高效抗逆转录病毒治疗患者体内残留的HIV-1复制。在接受高效抗逆转录病毒治疗前表现出持续高水平ANS活动的患者，在治疗3至11个月期间，血浆病毒载量抑制较差，CD4(+)T细胞恢复也较差。ANS活动与可能影响发病机制的人口统计学或行为特征无关。然而，ANS神经递质去甲肾上腺素通过趋化因子受体上调和增强病毒基因表达，在体外增强了HIV-1的CCR5嗜性和CXCR4嗜性毒株的复制，这表明神经活动可能直接促进残留病毒复制。
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