Kim J Y, Rosenfeld S R, Keyak J H
Department of Orthopaedic Surgery, University of California, Irvine, California, USA.
J Pediatr Orthop. 2001 Nov-Dec;21(6):765-6.
Turner syndrome (TS) is associated with multiple skeletal abnormalities. However, the prevalence of scoliosis in children with TS has not been reported in the orthopaedic literature. The purpose of this study was to determine the prevalence and characteristics of scoliosis in these patients. The authors performed a retrospective study of 43 patients with TS and found 5 children with a curve >10 degrees. The prevalence of scoliosis in this TS population, 11.6%, was significantly greater than the reported prevalence of idiopathic scoliosis in normal girls, 2.4%. The mean age of onset was 9 years 11 months. All curves were >34 degrees, with curves consisting of a right thoracic or S-shaped (larger lumbar segment) pattern. At the time of scoliosis presentation, two patients were not receiving growth hormone therapy. The results of this study suggest that children with TS need to be examined and closely monitored for progression of scoliosis by orthopaedists. Although curve progression can occur during growth acceleration, a direct causal association with growth hormone has not been established.
特纳综合征（TS）与多种骨骼异常有关。然而，骨科文献中尚未报道TS患儿脊柱侧弯的患病率。本研究的目的是确定这些患者脊柱侧弯的患病率和特征。作者对43例TS患者进行了回顾性研究，发现5例患儿的侧弯角度>10度。该TS人群中脊柱侧弯的患病率为11.6%，显著高于正常女孩特发性脊柱侧弯的报告患病率2.4%。平均发病年龄为9岁11个月。所有侧弯角度均>34度，侧弯类型为右胸弯或S形（腰段较大）。在脊柱侧弯出现时，有两名患者未接受生长激素治疗。本研究结果表明，TS患儿需要接受骨科医生的检查，并密切监测脊柱侧弯的进展情况。虽然在生长加速期可能会出现侧弯进展，但尚未确立与生长激素的直接因果关系。
