Zanocchi M, Risso R, Maero B, Aimar T, Giona E, Francisetti F, Maina P, Fabris F
Dipartimento di Discipline Medico-Chirurgiche, Sezione di Geriatria, Università degli Studi, Turin, Italy.
Minerva Med. 2001 Oct;92(5):307-13.
The aim of this study was the assessment of Deep Venous Thrombosis (DVT), and its relationship with malignant neoplasm in elderly.
The study sample included six-hundred patients admitted to the University Department of Geriatric Medicine in Turin in 1997 (332 male and 268 female, mean age 77.7+/-8 year). Not-neoplastic subjects affected with DVT were followed up for two years. We analysed incidence of malignant cancer in this group and then it was compared with incidence of new neoplasm in subjects without DVT at baseline.
Prevalence of deep venous thrombosis at hospital admission and during the hospitalization was 4.8%. About 50% of patients with DVT had a related neoplastic disease. Patients with DVT were affected with malignant disease four times more than subjects without DVT. The risk of a neoplasm, during the two-years follow-up, was 6.8 times higher for patients with DVT at baseline in comparison with elderly without DVT. We didn't find significative differences between subjects with primary DVT and elderly with DVT due to neoplasm.
There is a wide association between DVT and malignant disease. For this reason a careful follow-up of people with DVT is recommended.
本研究旨在评估老年患者深静脉血栓形成（DVT）及其与恶性肿瘤的关系。
研究样本包括1997年入住都灵大学老年医学科的600例患者（男性332例，女性268例，平均年龄77.7±8岁）。对非肿瘤性DVT患者进行了两年的随访。我们分析了该组恶性肿瘤的发病率，然后将其与基线时无DVT患者的新发肿瘤发病率进行比较。
入院时及住院期间深静脉血栓形成的患病率为4.8%。约50%的DVT患者患有相关的肿瘤性疾病。DVT患者患恶性疾病的几率是无DVT患者的四倍。在两年的随访期间，基线时有DVT的患者发生肿瘤的风险比无DVT的老年人高6.8倍。我们未发现原发性DVT患者与因肿瘤导致DVT的老年患者之间存在显著差异。
DVT与恶性疾病之间存在广泛关联。因此，建议对DVT患者进行密切随访。
