Goldberg R J, Seneff M, Gore J M, Anderson F A, Greene H L, Wheeler H B, Dalen J E
Arch Intern Med. 1987 Feb;147(2):251-3.
An association between venous thrombosis and cancer was first suggested by Armand Trousseau and subsequently confirmed by multiple postmortem studies. In a previous study, patients with pulmonary embolism, as assessed by pulmonary angiography, were at significantly increased risk of occult cancer with a comparison group of patients without pulmonary embolism. This nonconcurrent prospective epidemiologic study extends these findings by demonstrating a significantly increased risk of occult cancer in patients with deep venous thrombosis (DVT) confirmed by impedance plethysmography as compared with those with suspected DVT in whom the diagnosis was ruled out. Differences in the incidence of malignant neoplasms were greatest within the first two years after the diagnosis of DVT, and patients younger than 50 years with venous thrombosis were at particularly increased risk of occult cancer (relative risk, 19.0). These findings indicate that all patients with DVT or pulmonary embolism should have an appropriate diagnostic workup and careful follow-up, particularly with regard to the risk of occult cancer.
静脉血栓形成与癌症之间的关联最早由阿尔芒·特鲁索提出，随后多项尸检研究证实了这一点。在之前的一项研究中，经肺血管造影评估，肺栓塞患者患隐匿性癌症的风险显著高于无肺栓塞的对照组患者。这项非同期前瞻性流行病学研究扩展了这些发现，表明经阻抗体积描记法确诊为深静脉血栓形成（DVT）的患者患隐匿性癌症的风险显著高于疑似DVT但诊断被排除的患者。恶性肿瘤发病率的差异在DVT诊断后的头两年内最为明显，50岁以下的静脉血栓形成患者患隐匿性癌症的风险尤其增加（相对风险，19.0）。这些发现表明，所有DVT或肺栓塞患者都应进行适当的诊断检查和仔细的随访，尤其是考虑到隐匿性癌症的风险。
