Ito Y, Utsugi T, Ohyama Y, Ohno T, Uchiyama T, Tomono S, Kawazu S, Kurabayashi M
Second Department of Internal Medicine, Gunma University School of Medicine, Japan.
J Int Med Res. 2001 Jul-Aug;29(4):280-6. doi: 10.1177/147323000102900403.
This 7-year retrospective longitudinal study was carried out in order to clarify the clinical features of elderly type 2 diabetic patients with microalbuminuria. Elderly Japanese type 2 diabetic patients (n = 22; age 50 - 73 years) with microalbuminuria were studied retrospectively. Patients whose urinary albumin excretion rate (UAER) decreased 7 years were considered 'nonprogressors' (n = 8) whereas those whose UAER increased were considered 'progressors' (n = 14). The mean 7-year level of glycosylated haemoglobin (HbA1c) did not differ significantly between non-progressors and progressors but the mean 7-year blood pressure (BP) of progressors (101 +/- 8 mmHg) was significantly higher than that of non-progressors (92 +/- 7 mmHg). In progressors who received no anti-hypertensive drugs, systolic BP was above the BP goal of 130/85 mmHg but mean BP and diastolic BP were below this goal. The results are consistent with the view that hypertension affects the progression of microalbuminuria; raised systolic BP may be a factor in this progression in elderly type 2 diabetic patients.
这项为期7年的回顾性纵向研究旨在阐明老年2型糖尿病微量白蛋白尿患者的临床特征。对老年日本2型糖尿病微量白蛋白尿患者（n = 22；年龄50 - 73岁）进行回顾性研究。尿白蛋白排泄率（UAER）7年未升高的患者被视为“非进展者”（n = 8），而UAER升高的患者被视为“进展者”（n = 14）。非进展者和进展者的7年糖化血红蛋白（HbA1c）平均水平无显著差异，但进展者的7年平均血压（BP）（101 +/- 8 mmHg）显著高于非进展者（92 +/- 7 mmHg）。在未接受抗高血压药物治疗的进展者中，收缩压高于130/85 mmHg的血压目标，但平均血压和舒张压低于该目标。结果与高血压影响微量白蛋白尿进展的观点一致；收缩压升高可能是老年2型糖尿病患者微量白蛋白尿进展的一个因素。
