Saple D G, Amar A K, Ravichandran G, Korde K M, Desai A
Grant Medical College and GT Hospital, Mumbai.
J Indian Med Assoc. 2001 May;99(5):274-5.
Superficial dermatophytoses of skin are very common infections seen in clinical practice. Besides topical imidazoles, triazoles and allylamines, topical butenafine (a benzylamine derivative) is a novel agent with broad antifungal activity. One hundred and eleven patients with tinea infections were enrolled in this multicentric, randomised, single-blind non-comparative study, which involved application of butenafine (1%) cream in tinea pedis (4 weeks) and tinea cruris and tinea corporis (2 weeks) cases. The results showed that butenafine causes rapid resolution of signs and symptoms (erythema itching, burning, crusting, scaling, etc), with good patient and physician acceptability of treatment. The broader spectrum fungicidal activity and better drug retention in superficial skin layers may be responsible for this beneficial effect.
皮肤浅表皮肤癣菌病是临床实践中常见的感染。除了外用咪唑类、三唑类和烯丙胺类药物外，外用布替萘芬（一种苄胺衍生物）是一种具有广泛抗真菌活性的新型药物。111例癣感染患者参加了这项多中心、随机、单盲非对照研究，该研究涉及在足癣（4周）、股癣和体癣（2周）病例中应用1%布替萘芬乳膏。结果表明，布替萘芬可迅速缓解体征和症状（红斑、瘙痒、灼痛、结痂、脱屑等），患者和医生对治疗的接受度良好。更广泛的杀菌活性和在浅表皮肤层更好的药物保留可能是产生这种有益效果的原因。
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