Singal Archana
University College of Medical Sciences & GTB Hospital, Department of Dermatology & STD, Delhi - 110095, India.
Expert Opin Drug Metab Toxicol. 2008 Jul;4(7):999-1005. doi: 10.1517/17425255.4.7.999.
Butenafine hydrochloride, a benzylamine derivative, exhibits potent fungicidal activity particularly against dermatophytes, aspergilli, dimorphic and dematiaceous fungi.
To review pharmacokinetics, mechanism of actions and clinical efficacy of butenafine against various dermatophytic and other superficial fungal infections.
Medline search was made using keyword butenafine. All English language articles were considered for this review. For inclusion in clinical efficacy section when ever available randomized controlled trials were considered a priority over other trials.
RESULTS/CONCLUSIONS: The drug has excellent penetration into the epidermis and a prolonged retention time following topical application, conferring residual therapeutic activity after treatment cessation. Butenafine possess anti-inflammatory activity too. Topical butenafine 1% cream has been reported to be efficacious for tinea pedis, tinea corporis and tinea cruris in many randomized clinical trials when used for shorter duration. Its efficacy against pityriasis versicolor, seborrheic dermatitis and as anticandidal agent is not yet fully established.
盐酸布替萘芬是一种苄胺衍生物，具有强大的杀真菌活性，尤其对皮肤癣菌、曲霉菌、双相真菌和暗色真菌有效。
综述布替萘芬对各种皮肤癣菌及其他浅表真菌感染的药代动力学、作用机制和临床疗效。
使用关键词“布替萘芬”进行医学文献数据库检索。本次综述纳入所有英文文章。在临床疗效部分，只要有随机对照试验，优先纳入，其他试验次之。
结果/结论：该药物经局部应用后可很好地渗透入表皮，且保留时间延长，停药后仍具有残余治疗活性。布替萘芬还具有抗炎活性。在许多随机临床试验中，1%布替萘芬乳膏用于较短疗程时，已被报道对足癣、体癣和股癣有效。其对花斑癣、脂溢性皮炎的疗效以及作为抗念珠菌药物的疗效尚未完全确立。
