瓣膜置换在真菌性心内膜炎治疗中的作用。
The role of valve replacement in the treatment of fungal endocarditis.
作者信息
Utley J R, Mills J, Roe B B
出版信息
J Thorac Cardiovasc Surg. 1975 Feb;69(2):255-8.
The role of valve replacement in the treatment of fungal endocarditis has not been defined. The diagnosis of fungal endocarditis was made in 11 patients, 8 before death and 3 at autopsy. Nine patients were infected with Candida species, one with Torulopsis glabrada and one with Aspergillus. None of the 8 patients whose disease was diagnosed during life was cured despite up to 160 days of amphotericin B therapy. All required valve replacement for heart failure (1 patient), emboli (1 patient, or both (6 patients). We recommend early valve replacement for fungal endocarditis before the onset of heart failure and emboli.
瓣膜置换术在真菌性心内膜炎治疗中的作用尚未明确。11例患者被诊断为真菌性心内膜炎，其中8例在死亡前确诊，3例在尸检时确诊。9例患者感染念珠菌属，1例感染光滑球拟酵母菌，1例感染曲霉菌。尽管接受了长达160天的两性霉素B治疗，但8例生前确诊疾病的患者均未治愈。所有患者均因心力衰竭（1例）、栓塞（1例）或两者兼具（6例）而需要进行瓣膜置换。我们建议在心力衰竭和栓塞发作前，对真菌性心内膜炎尽早进行瓣膜置换。
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